A U5 repressor of reverse transcription is required for optimal HIV-1 infectivity and replication
نویسندگان
چکیده
Address: 1Griffith Medical Research College, a joint program of Griffith University and the Queensland Institute of Medical Research, QIMR, Herston, QLD, Australia, 4006, 2Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Brisbane 4029, Qld, Australia and 3Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 rue René Descartes, 67084 Strasbourg cedex, France * Corresponding author
منابع مشابه
Stabilization of the U5-leader stem in the HIV-1 RNA genome affects initiation and elongation of reverse transcription.
Reverse transcription of the Human Immunodeficiency Virus type I (HIV-1) RNA genome is primed by a cellular tRNA-lys3 molecule that binds to the primer binding site (PBS). The PBS is predicted to be part of an extended RNA structure, consisting of a small U5-PBS hairpin and a large U5-leader stem. In this study we stabilized the U5-leader stem of HIV-1 to study its role in reverse transcription...
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ورودعنوان ژورنال:
- Retrovirology
دوره 6 شماره
صفحات -
تاریخ انتشار 2009